Examine This Report on Thai Betting Portals
Examine This Report on Thai Betting Portals
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). The protein-DNA interface entails intensive DNA contacts by the NTase, OB, and HhH domains about a 19-bp phase of duplex DNA centered with regards to the nick (supplemental Fig. S3). The NTase area binds to the broken DNA strands at and flanking the nick; the OB domain contacts the continuous template strand surrounding the nick; as well as HhH area binds each strands throughout the slight groove for the periphery of your footprint.
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All archaeal proteomes incorporate an ATP-dependent DNA ligase that resembles in all structural respects (amino acid sequence; conservation of NTase motifs, which include motif VI; and tertiary composition composed of the N-terminal DBD plus the central NTase and C-terminal OB domains) (20, 21) the canonical ATP-dependent DNA ligases of eukaryal cells. Biochemical characterization of many archaeal DNA ligases confirmed their demanding dependence on ATP and failure to utilize NAD+ (summarized in Ref. 22). By contrast, other archaeal ligases had been reported to possess “twin specificity,” variously using ATP and
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